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DNA fragmentation can significantly impact fertility, even in men with otherwise normal semen parameters. Here's what you need to know:
Prevalence of High DNA Fragmentation:
- Affects 11% of men with normal semen parameters
- Impacts up to 39% of men with abnormal semen parameters
Potential Consequences of High DNA Fragmentation:
- Reduced natural conception rates
- Increased risk of miscarriage
- Lower success rates with Intrauterine Insemination (IUI) and conventional In Vitro Fertilization (IVF)
- Potential developmental issues in embryos
Routes for Treatment:
The good news is that 40-70% of DNA fragmentation-related fertility issues are potentially solvable with lifestyle improvements and medical intervention. This highlights the importance of early detection and appropriate treatment.
The Mojo DNA Fragmentation Test is highly recommended for:
- Couples struggling with unexplained infertility (over 6 months of trying)
- Couples experiencing recurrent miscarriages
- Those with poor embryo quality during IVF
- Men over 40 years of age
- Men with a history of cancer or those on certain medications
- Men with unhealthy lifestyle habits (e.g., smoking) or a BMI over 30
- Men facing unexplained male infertility despite normal semen analysis
This test is crucial for identifying underlying issues that may not be detected through standard semen parameters.
Mojo uses the Sperm Chromatin Structure Assay (SCSA), recognized globally as the gold standard in sperm DNA testing. Here's why:
- Comprehensive Analysis: Measures both DNA Fragmentation Index (DFI) and High DNA Stainable (HDS) fraction
- Unmatched Accuracy: Highest precision and reproducibility in the field
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Clear Clinical Relevance: Results directly linked to pregnancy outcomes:
- <15% DFI: Excellent to good
- 15% to <25% DFI: Good to fair
- 25% to <40% DFI: Fair to poor
- ≥40% DFI: Very poor
- Unexplained Infertility Insights: Helps identify hidden fertility challenges
- Rigorous Process: UK samples processed at TDL London, measured at University of Kent
- Globally Trusted: Preferred by fertility specialists worldwide
- Superior Technology: Outperforms other methods (e.g., SDC, Comet) in analysis depth and fertility correlation
Mojo's SCSA test provides the UK's most accurate DNA fragmentation analysis, empowering informed fertility decisions.