Sperm DNA fragmentation:

• Breaks in DNA strands within sperm cells
• Measures genetic integrity of sperm
• Can significantly impact male fertility
• High levels associated with:
  • Delayed conception
  • Recurrent miscarriages
  • Failed IUI/IVF treatments
• Can affect men with normal sperm count, motility, and morphology
• Provides insights into unexplained infertility
• Helps guide appropriate fertility treatments

DNA fragmentation can significantly impact fertility, even in men with otherwise normal semen parameters. Here's what you need to know:

Prevalence of High DNA Fragmentation:

• Affects 11% of men with normal semen parameters
• Impacts up to 39% of men with abnormal semen parameters

Potential Consequences of High DNA Fragmentation:

• Reduced natural conception rates
• Increased risk of miscarriage
• Lower success rates with Intrauterine Insemination (IUI) and conventional In Vitro Fertilization (IVF)
• Potential developmental issues in embryos

Routes for Treatment:

The good news is that 40-70% of DNA fragmentation-related fertility issues are potentially solvable with lifestyle improvements and medical intervention. This highlights the importance of early detection and appropriate treatment.

The SCSA-based Sperm DNA Fragmentation Test is highly recommended for:

• Couples struggling with unexplained infertility trying to conceive for over a year
• Couples experiencing recurrent miscarriages
• Those with poor embryo quality during IVF
• Men with clinical varicocele
• Men after varicocele repair
• Men over 40 years of age
• Men with a history of cancer or those on certain medications
• Men with unhealthy lifestyle habits (e.g., smoking) or a BMI over 30
• Men facing unexplained male infertility despite normal semen analysis

This test is crucial for identifying underlying issues that may not be detected through standard semen parameters.

The Sperm Chromatin Structure Assay (SCSA) is recognised globally as one of most standardised assays in sperm DNA testing.

Here is why:

• Comprehensive Analysis: Measures both DNA Fragmentation Index (DFI) and High DNA Stainable (HDS) fraction
• High standardisation: Low variability in the procedure and comparability among different labs worldwide
• Clear Clinical Relevance: Results directly linked to pregnancy outcomes:
  • <15% DFI: Excellent to good
  • 15% to <25% DFI: Good to fair
  • 25% to <40% DFI: Fair to poor
  • ≥40% DFI: Very poor
• Unexplained Infertility Insights: Helps identify possible causes of infertility
• Rigorous Process: ISO accredited, CE marked test, UK samples processed at TDL Andrology (London), measured at University of Kent
• Globally Trusted: 100's of publications on SCSA-based assay - used worldwide
• Advanced Technology: The SCSA-based test is a rapid, non-biased flow cytometer machine measurement providing robust statistical data with high precision and repeatability

Due to the high standardisation, results are globally comparable.

The SCSA-based Sperm DNA Fragmentation test provides the UK's most standardised and low-cost sperm DNA fragmentation analysis, empowering informed fertility decisions.

At LogixX Pharma, we prioritize both speed and accuracy.

Here's how Logixx delivers the fastest and most standardised DNA Fragmentation Test results in the UK:

• Sample Collection: Produce your sample at our partner facility: The Doctors Laboratory (TDL) 76 Wimpole St, London W1G 9RT, United Kingdom

• Immediate Processing: Your sample is immediately processed and flash-frozen on-site

• Secure Transport: The frozen sample is safely transported to the University of Kent

• Expert Analysis: Specialized equipment and trained professionals at the University of Kent conduct the SCSA analysis

• Rapid Results: You receive your results - typically less than 4 working days - the fastest turnaround time in the UK for this type of advanced test

This meticulous process ensures sample integrity and delivers the most reliable sperm DNA fragmentation results possible.